Why Liposomal Palmitoylethanolamide (PEA)

Why Liposomal Palmitoylethanolamide (PEA)

If you haven’t already read it, we would strongly recommend reading our entry on what liposomes are and how they work. Aside from giving great basis for understanding why liposomal palmitoylethanolamide is such a breakthrough, it also gives very valuable insight into the mechanism in general.

The two problems with PEA are the buildup period whose length depends on personal absorption capacities or each patient and the fact that it is metabolized by FAAH and NAAA enzymes. The problem with the enzymes is that they are very efficient and that they degrade PEA quickly. This greatly reduces the amounts of PEA that people with lower absorption capacities can take in and prolongs the buildup period.

Liposomal palmitoylethanolamide solves both of these problems.

The liposomal delivery system has been familiar since the 1960s. It has been polished and improved over the decades and now we have a lot of knowledge about the different kinds and benefits. Once again, if you are interested in it, I would recommend the link in the first paragraph of this text.

Speaking of PEA in particular, both the buildup period and fast degradation by the enzymes are solved with the liposomal delivery system.

Liposomes have several benefits. They are spherical structures with a phospholipid bilayer membrane. The PEA (or any active content, vitamin, drug, nutraceutical…) is safely tucked in within the liposome. The phospholipid membrane is the same as the cell membrane and it protects PEA from stomach acids and enzymes.

This means that PEA can be delivered straight to the cells where it is needed, without much of it being digested and broken down on the way. 

What happens when a liposome reaches the cell?

We have already talked about our limited absorption capacities. However, when a liposome reaches a cell, the liposome membrane integrates into the cell membrane due to the mentioned biocompatibility of their phospholipid bilayers membranes.

Liposomal delivery system palmitoylethanolamide
Liposome Fusion

This means that all of the PEA is delivered into the cell and not wasted. It is the mechanism that works the same for any kind of active content and it is a well known benefit of liposomes that fixes the bioavailability issue.

The result?

Taking up to 7.5 ml liposomal palmitoylethanolamide a day equals the amount of taking 4 capsules, but the effects are much greater, since none of it is destroyed by the enzymes and stomach acids. If you are having problems with bioavailability of PEA, you should try liposomal PEA.

However, you should be advised of the additional ingredients in the liposomes. None of them are considered dangerous, but for example, they may contain soy, so people with soy allergies should know this.

Make sure you read the ingredients on your liposomal PEA bottle and be sure that you can take it.

If you would like to learn more information about the liposomal delivery system, click here .