Chronic skin pain is a common condition caused by diabetes, together with many other conditions including toe arthritis. The new pain-relieving and anti-inflammatory PEA cream is now available in the United States. A number of patients have reported positive experiences after the use of this cream. Following is an example.
Case Study on CIAP
A patient is presented with a particular condition, called Chronic Idiopathic Axonal Polyneuropathy (CIAP). The patient complains of nausea, burning, and stabbing pain in the feet. The pain is of severe nature, which scores up to seven on a scale of 0-10.
After applying a cream containing adelmidrol (PEA molecules fused together) on the feet, the intensity of pain decrease significantly (reports of 0 or 1 on the scale) within 20 minutes. We have observed that this cream tends to increase the levels PEA in the skin. The levels of PEA can also be directly increased by the aid of a non-OTC (over the counter) PEA cream with significant purity.
This means that increased amounts of PEA in the body have a greatly positive effect and not a single side effect or negative interaction with medicines. This is understandable, having in mind that it is an endogenous substance, produced by the body to defend itself. However, for chronic conditions the produced amounts are not sufficient and additional amounts are necessary.
Treatment of painful feet with PEA Cream
PEA cream contains substances that relieve pain through an anti-inflammatory effect. The mode of action performed by the cream is associated with the production of pain relieving and anti-inflammatory substances in the body, specifically in conditions underpinned with pain and infection. In cases such as neuropathic pain, the production these substances is too low, while the application of PEA cream can provide assistance to the body in maintaining the substances production. In addition to this, reduction in pain is often noticed within a short period of time.
Pain Relieving Effects of PEA Cream
The pain relieving cream containing adelmidrol was manufactured by the fusion of two molecules of palmitoylethanolamide together, which essentially can also be a synthetic unnatural molecule. However, there are PEA creams produced containing only the natural PEA molecule.
Scientific Research of Adelmidrol and PEA
Adelmidrol and PEA are fatty acids that penetrate through the skin easily and can create a localized pain relieving and anti-inflammatory effect. A test conducted on a very severe infection by including adelmidrol, indicated that adelmidrol clearly decreased inflammation.  In another study on children presented with cases of inflamed skin conditions, entailing pain and itching, adelmidrol and PEA both turned out to be effective and safe. 
Adelmidrol also proved useful for dogs with severe inflammation of the teeth.
 De Filippis D, D’Amico A, Cinelli MP, Esposito G, Di Marzo V, Iuvone T. (2008 Apr 18). Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. J Cell Mol Med.
 Pulvirenti N, Nasca MR, Micali G. (2007). Topical adelmidrol 2% emulsion, a novel aliamide, in the treatment of mild atopic dermatitis in pediatric subjects: a pilot study. Acta Dermatovenerol Croat.
 Bonello D, Squarzoni P. (2008 Mar). Effect of a mucoadhesive gel and dental scaling on gingivitis in dogs.J Vet Dent.