Palmitoylethanolamide is completely safe. After more than 400 studies conducted in various parts of the world and over the course of more than 60 years, there are no recurring side effects that can be attributed to PEA. In some older studies some patients experienced mild discomfort in the stomach, but this was attributed to a sweetener sorbitol that was used. Modern PEA capsules formulations include not a single added ingredient aside from pharmaceutical grade palmitoylethanolamide and a vegetarian capsule, so there is no problem with sorbitol.
But, let’s have a closer look at the safety of PEA.
First of all, there is no overdose level. PEA can be taken in any amount without any dangers of overdose. All of it that is not absorbed is dissolved very quickly by two cellular enzymes named FAAH and NAAA. They are extremely effective and they leave no excess PEA in the body.
However, even if it were not dissolved, there is no known issue with having PEA in the body.
Secondly, side effects are virtually non-existent. PEA is naturally present in the body and produced there as well. It has been a part of many single-cell organisms such as yeast cells, as well as many plants and animals, so it is well established in nature and basically a part of evolution. This means that it has gone through all of the adaptation processes and that it works with the rest of the body. Having side effects from PEA would be like having side effects from anything naturally present in the body.
Next, habituation is not an issue. By habituation we mean the very common case of a patient getting used to the medicine. This is the root of many issues with various medicines. For example, many people take painkillers which have side effects, but they eliminate pain efficiently. As the person’s body gets used to the painkiller it needs more of it to provide the same pain relief. However, side effects of painkillers often forbid increasing the amounts and they often surpass the painkilling benefits. The end result is that the person can either increase the amount of painkillers and cause serious issues coming from the side effects, or they can stay within the safe amounts which are no longer sufficient to ease the pain. Either way, the adverse results greatly surpass the benefits.
This is most noticeable with chronic conditions since, unlike with the short-term pain issues, pain is a constant problem and habituation is often inevitable.
PEA has no habituation issues. In fact, the more you take it, the more it builds up in the body and the more effective it is.
Next, there have been no reports of allergic reactions to PEA. This is easily explained by its centuries-long presence in the body. It would be like being allergic to something that is present in the body naturally.
Similarly, there are no negative interactions with drugs. This is a major safety and efficacy benefit of PEA. It is also easily explainable by understanding that PEA is naturally produced in the body, so if any medicine had a negative interaction with it, it would simply not exist, since it could not be used.
This is a major benefit! It means that PEA can be used alongside other drugs, for example painkillers, which means you can take it and build up the amounts while the painkiller takes care of the pain before PEA builds up. As the buildup increases, patients can reduce the amounts of painkillers or exclude them completely.
In today’s world of medicines, having complete safety is a major and very rare benefit that PEA proudly boasts.