MS: multiple sclerosis patients and experiences with PEA

MS: multiple sclerosis patients and experiences with PEA

The MS Association’s magazine, contained a long article about the value of the natural supplement with the difficult name palmitoylethanolamide (PEA) in the occurrence of MS,  chronic pain and spasms. The article drew a lot of attention. Issue number 3 contained a colophon about it, and issue number 4 of this year talked about using palmitoylethanolamide with MS.

PEA is an endogenous substance  with an anti-inflammatory and pain-relieving effect. The supplement  PEA is now globally used  by almost a million people. Since 2015, approximately one thousand people have been taking it since 2015.

Below, you will find those experiences of MS patients using PEA. The quotes are gathered from forums on which information is collected about the efficacy of PEA. Patients also sent us their own experiences by email.


MS, pain, stiff joints, and PEA

I have taken PEA for 5 weeks no. On the 20th day, I woke up in the morning without a painful back and joints, also without the incredible stiffness in all my limbs and back, while the day before I was not even able to lift my arms. So, I cleaned the whole house, the beds, and then went to the gymnastics. The following day, NO aches nor stiffness.

I notice that all body movements are much better, that I however do get tired. So I should (and can) build up condition, as I am out of shape. I wake up every morning and am astonished that I can get out of bed so easily without any pain.

No Amitriptyline and Lyrica in case of MS pain…but PEA! 

I also started using PEA after reading the article on  It makes a huge difference! As various products (Lyrica, Amitriptyline), prescribed by my neurologist, gave no results, and because his message that nerve pain is difficult to treat and can only be “soothed” to a certain extent, I gave up all courage to get rid of it. I now use 1x 600 and 1x 300 mg per day and can confirm: the pain has gone for 90%.

Severe debilitating pain with MS and PEA

I have already been using PEA for 6 weeks and have seen some improvement, approximately 25% less pain. Please tell me that this is reason for the pain reduction after a dose of PEA during 6 weeks.

I suffered a debilitating pain before using PEA and do not want to return to that feeling. I could not stand it any longer. Thank you. Ruth Anne Ruthan

PEA, MS pain and the sun

This morning, I took my last PEA pill. I promised that I would tell how things were going after having finished all my sachets and tablets. The reason for starting with PEA: sensory disorders in upper legs, pain in the neck (herniated disc/wear), painful knees and foot pain. When starting to use the sachets, the pain seemed to diminish, first at the back of the neck, then also the feeling in the upper legs and feet improved.

My knees remained painful. When I started taking the pills, it seemed to take effect but …. in the period I started taking PEA, the sun began to shine and it became increasingly warmer, which also has a beneficial effect on my body. Unfortunately…with the rain and cold of the last days, I suffer from the same complaints (except for my neck) as before. I now wait to see how it will evolve.

If necessary, I will start again taking the sachets, since they seem to give the best result. My advice is: do not be discouraged by the experience of others, find your own good advice and do what feels right for YOU and….listen to your body!

PEA and no more tingling with MS

I started with PEA around April 18, 2016, mainly because I suffered a lot from burning pains in hands, feet and legs. The pain scored a 7 on 10 (10 is maximum imaginable pain). In addition, I had a loss of strength in my legs and suffered from general fatigue. Also tingling in hands, feet and legs.

I started taking the PEA powders under the tongue and within 10 days only I noticed a decrease in pain and improvement of strength in my legs! I noticed that the effect remained good and that after almost 3 weeks my pain  scores 3 on 10, so really much better….

The tingling has not disappeared, but the strength in my legs seems to have become better, I feel more energetic. The burning feeling has completely gone.

PEA and better and stronger 

I have been taking PEA against my MS pain and fatigue for 2 months now. I must say that  the pain is much less, and I have the feeling that the MS is also responding well. I feel better, stronger, is that possible? And I can finally sleep without pain!

MS and spasms: PEA instead of Baclofen 

I have been using PEA for a few months now. In first instance as an alternative for Baclofen against spasms caused by MS . After approximately 1 month of using of 2 tablets 600 mg and 2 sachets per day, I switched to 2 tablets of 300 mg and 1 sachet.

Results : the spasms have largely become manageable, despite the fact that I go the gym 3x per week.  The restless feeling in my legs, especially at night, has disappeared. I also have the feeling that everything has become more stable, and by that I mean that controlling arms and legs feels far more stable and I have a less weak feeling in arms and legs. I should tell that after a sports night I take a 600 mg tablet, as it is more effective.

PEA: unfortunately l not the expected impact

Of course, there are also patients who do not benefit from PEA, as you will learn from the following example:

PEA: unfortunately not the expected impact

Hello I have been using for almost 40 days and still do not notice any difference. I got injections for my tail bone and legs again on Tuesday, this time at Optimal Care in New York. I could not stand on my legs anymore, it took half an hour before the feeling came back .They were very painful again, and now I have but to wait and see whether  they will have result this time. It was the fourth time, but the first time at this clinic in New York. You know, you try everything to make the pain go away, it drives you mad and you get frustrated. You really feel old. Well, I do hope for better days ahead.

Comment of PEA with MS

MS is a particular disease, with unpredictable symptoms and an erratic flow. That is why the most important arbitrator of the effect of PEA is: people themselves with their pain and spasms. If they know their body well, most people who suffer from MS will be able to form a judgment on what PEA has done for them. PEA seems to give good results in reducing pain and painful spasms.

Italian neurologists share the same experience. Unfortunately,  there are only a few neurologists who have experience with PEA. Because PEA is a supplement, it remains outside the scope and thus outside the experience of the majority of anaesthesiologists and neurologists. And because there is no pharmaceutical industry behind it to make the product known and to commercialize it, the process of getting known is slow.

But because PEA virtually has no side effects, because it is easy to take, also together with other medication, without fear of adverse interactions, PEA deserves attention as a new and natural means to treat chronic pain and inflammation.

MS and PEA 600 mg twice a day: largely pain free

The palmitoylethanolamide now seems really to have effect. After 56 days of using 2 x 600 mg per day, I have been largely pain free for the largest part of the day since a day or 3! After nearly a year of chronic pain for a large part of the day, this feels wonderful!

The PEA starter protocol 

I did not follow the procedure about the switch from sachets to tablets as indicated in the starters’ Protocol. I did try, but the tablets of 600 mg were no success; I think I did not absorb  the active substance well enough, that my stomach got affected by those large tablets, and therefore quickly developed resentment against those tablets.

Prefer the PEA sachets to the capsules

After 1 package, I  ordered the sachets again and went on using them. I read on the Internet that this was no problem, that the blood level gets a little higher faster, and it worked much better. Slowly but surely both the pain intensity and pain length decreased with normal physical strain (it returns at times of heavy physical strain, stress or fatigue, so enough rest and doing things calmly are very important).

Reducing PEA dosages with Ms 

Since today, I have moved on to a 300 mg tablet in the morning, and a 600 mg sachet in the evening. I have to wait and see whether it will work well. A nice additional feeling is that I have been having much less often nocturnal pain in my legs and feet, something I had been suffering from very often and severely over the last few years. This is probably also the result of taking PEA.

Anyway, I have the general feeling that my inner body seems calmer than it has since a long time, perhaps the anti-inflammatory effect of PEA plays a role in this.

I plan to keep on using it for now and to reduce PEA gradually on intuition to see, feel (!) how it will go. I did understand that it is no problem to keep on taking it for a longer time (maybe you can inform me on that?) and will keep you informed of developments.

PEA has some particular properties, especially for MS

  1. It is a natural inflammation modulator: spiralling auto-immune processes are normalized by PEA patients with disease symptoms similar to MS, such as dermatitis, psoriasis, rheumatism, ulcerative colitis and that kind of auto-immune processes, often respond very well to treatments with PEA. The inflammatory processes disappear. The chronic bladder pain syndrome for example, a process similar to MS but taking place in the bladder wall, also responds well to PEA.
  2. In experiments with mice that developed a type of MS, PEA seems to stop the inflammation, as well as MS phenomena such as paralysis.
  3. PEA has many similarities with cannabis, but not the effects on the consciousness, you will not get stoned or high.
  4. PEA can reduce painful spasm and neuropathic pains. The initial dose is always 600 mg twice a day. Sometimes it can be useful to increase the dose after a month. Always consult a doctor. If a general practitioner or neurologist cannot provide an answer, then ask a natural physician for advice.
  5. PEA can be taken with MS-medication without problem, with Baclofen, interferon, etc.
  6. Also older patients can use PEA without fear of problems driving a car or thinking.
  7. PEA supports the natural healing power of our body.