Improving delivery and absorption of PEA
For any drug, nutraceutical or vitamine taken orally, a part of it gets wasted before it is delivered to the targeted cells. Liposomes are the solution and liposomal PEA is the next step in bringing its effectiveness to a whole new level.
Liposomes have a few benefits:
– Liposomes deliver PEA directly to the cells that need it
– Liposomes deliver the entire amount of PEA by protecting it from the stomach acid and enzymes which would otherwise dissolve a part of it before it would reach the cells
– Liposomeal mechanism provides total absorption into a cell through its interaction with the cell membrane.
This means that PEA will not be digested, broken down or wasted due to the lack of absorption capacities. This way PEA’s positive effects are greatly increased without compromising safety, purity or cost efficiency.
Here is what you need to know about liposomes and liposomal PEA:
– What are liposomes?
– How do liposomes work?
– What is liposomal PEA?
– Why is it superior to any other PEA-based product on the market?
What are liposomes?
Liposome is a spherical structure consisted of a lipid bilayer which encloses some kind of a fluid. They are used to transfer active content of a drug to the needing cell and deliver it in its full capacity.
The main part of a liposome is its membrane which is phospholipid. Phospholipids have a head which is water soluble and tail which is fat soluble which allows liposomes to carry both water- and fat-soluble drugs.
In an aqueous environment phospholipids form into a thermodynamically stable structure – bilayer. This bilayer curves and makes a ball-like structure which encapsulates the active molecules, or in the case of liposomal PEA (palmitoylethanolamide).
Liposomes are biodegradable and biologically inert. They are used to protect and deliver PEA without interfering with its features or purity.
How do liposomes work?
Cell membranes and liposomal membranes are both phospholipid. Phospholipids are polar lipids because the head part of them is water soluble while the fatty acid tail is fat soluble (non-polar). The tails mutually attract, while the heads seek the aqueous medium.
This means that they are stable and solid and that nothing can harm the active molecules inside the liposome for as long as the membrane is there.
Liposomes can carry both water- and fat-soluble drugs. As the liposome membrane gets broken down by enzymes and acids, this active substance gets released.
However, there is another, more significant mechanism of delivery that works through liposomes. Due to the fact that both liposomes and cells have the same phospholipid bilayer membranes, when liposomes are absorbed from the gastrointestinal tract into the bloodstream, their bilayer can fuse with the cell membranes’ bilayers and thus directly release inside the cell the drug which is encapsulated within the liposome. This means that the drug is delivered straight into the cell in its full capacity, not partially digested or dissolved by enzymes or hampered by the cell membrane.
The liposome gets to the cell and due to their biocompatibility, the cell’s phospholipid membrane opens to the liposome’s phospholipid membrane allowing the active molecule into the cell without any problems.
What is liposomal PEA?
Liposomal PEA is palmitoylethanolamide which is delivered into the cell by liposomes. Liposomes carry pure palmitoylethanolamide, devoid of any additives and fillers and protect it from the stomach acid, FAAH and NAAA enzymes which break down PEA inside our bodies or any other kind of detrimental effect.
This is unique and different from any other PEA-based product, since all the rest have the same three perils:
1. Their PEA is quickly broken down by the mentioned enzymes
2. A part of it is destroyed by the stomach acid before it reaches the bloodstream
3. Not all of the PEA that reaches the cells gets absorbed due to limited absorption capacity of humans
Liposomal PEA eliminates each and every of these perils and makes PEA even more efficient than it was before.
Why is liposomal PEA superior to any other PEA-based product on the market?
Before liposomal PEA, the most efficient way of delivering PEA products was in capsules. Capsules are far better than tablets because they allow modern manufacturers to provide the market with pure PEA without any excipients, fillers, additives or taste modifiers. The most efficient tablets had 60% of PEA, while the most efficient capsules go all the way up to >98% purity.
However, despite the purity, even capsules have their downsides. When a capsule goes into the stomach it is rapidly dissolved by the stomach acid. It releases PEA right there inside the stomach and this is not very good for absorption, since much of the content gets destroyed by the stomach acid and thus wasted.
Moreover, the part of PEA which does get delivered into the bloodstream is open for attacks before it is absorbed by cells. This is why, despite the capsule’s superiority to the tablets, not all PEA is delivered to the cells.
With liposomal PEA, PEA is completely protected until it reaches cells. When it does get there, the unique liposomal mechanism ‘unlocks’ the cell membrane, allowing the entire amount of PEA to get past it. Liposomal PEA is literally the sum of the benefits of PEA and liposomes.
This is how it works:
– Pure PEA encapsulated by a liposome is taken orally.
– PEA is a fatty acid so a part of it would be digested inside our stomach. However, liposome membrane protects it from the stomach acid.
– After that it gets delivered into the bloodstream which transfers it to the target cells.
– When it reaches the cell, due to the fact that the liposome phospholipid membrane is biocompatible to the cell phospholipid membrane, the liposome membrane gets integrated into the cell membrane, releasing the PEA content into the cell.
Aside from the PEA-protective function, liposomal PEA’s improved absorption greatly decreases the buildup period, since all of the PEA is delivered to the cell and absorbed by it. This allows patients to build up the levels of PEA far easier and experience the benefits sooner.
Liposomal PEA is by far the most superior PEA product on the market in terms of efficacy, safety and availability.