Chronic skin pain is a common condition caused by diabetes, together with many other conditions including toe arthritis. The new pain-relieving and anti-inflammatory PEA cream is now available in the United States. A number of patients have reported positive experiences after the use of this cream. Following is an example.
A patient is presented with a particular condition, called Chronic Idiopathic Axonal Polyneuropathy (CIAP). The patient complains of nausea, burning, and stabbing pain in the feet. The pain is of severe nature, which scores a seven on a scale of 0-10 and 10 is the most severe pain.
After applying a cream contained with adelmidrol (PEA molecules fused together) on the feet, the intensity of pain decrease up to 0 or 1 within 20 minutes. We have observed that this cream tend to increase the levels PEA in the skin. The levels of PEA can also be directly increased by the aid of a non-OTC (over the counter) PEA cream with significant purity.
Treatment of Painful feet with PEA Cream
A PEA cream contains substances that reliefs pain by the anti-inflammatory effect. The PEA cream is available with the name of palmitoylethanolamide. The mode of action perform by the cream is associated with the production of pain relieving and anti-inflammatory substances by the body itself, specifically in conditions underpinned with pain and infection. In cases such as neuropathic pain, the production these substances are too low, while the application of PEA cream can provide assistance to the body in maintaining the substances production. In addition to this, reduction in pain is often noticed within a short duration of time.
Pain Relieving Effects of PEA Cream
The pain relieving cream contained with adelmidrol was manufactured by the fusion of two molecules of palmitoylethanolamide together, which essentially can also be a synthetic unnatural molecule. Currently, a cream is now made available that contains only the natural PEA molecule.
Scientific Research of Adelmidrol and PEA
Adelmidrol and PEA are fatty acids that penetrate through the skin easily and can create a localized pain relieving and anti-inflammatory effect. A test conducted on a very severe infection by including adelmidrol, similar to that of cancer, indicated that adelmidrol clearly decreased inflammation.  In another study on children presented with cases of inflamed skin conditions, entailing pain and itching, adelmidrol and PEA both turned out to be effective and safe. 
Adelmidrol also proved useful for dogs with severe inflammation of the teeth, the inflammation decreased considerably.
 De Filippis D, D’Amico A, Cinelli MP, Esposito G, Di Marzo V, Iuvone T. (2008 Apr 18). Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. J Cell Mol Med.
 Pulvirenti N, Nasca MR, Micali G. (2007). Topical adelmidrol 2% emulsion, a novel aliamide, in the treatment of mild atopic dermatitis in pediatric subjects: a pilot study. Acta Dermatovenerol Croat.
 Bonello D, Squarzoni P. (2008 Mar). Effect of a mucoadhesive gel and dental scaling on gingivitis in dogs.J Vet Dent.