If you are familiar with the positive effects of medical marijuana, but you are worried because of the negative ones, or the strict legislation, you are in the right place. Of the three compounds from the title, one is more efficient than the others, safer, legal everywhere in the world and thoroughly tested by scientists. This is one place where you can have the best of all worlds and not forced to be satisfied with compromises.

Let’s start with why these three are even compared. PEA, THC and OBD are all natural substances which affect certain receptors within our cells and thus help with acute or chronic pain and inflammation. They can also affect both blood and nerve cells, so they can help with various conditions. But their differences are what makes one of them the best choice. Let’s start with the least effective one.


Probably the most familiar acronym and there are probably people who will not be happy learning that THC is the worst choice of the three. However, we are not negating its efficacy e2lnlmw. THC has been scientifically proven to bind to several receptors and provide relief against pain. There is no question about that.

However, the first negative point regarding THC is that it is psychoactive. Many people are familiar with the sensation that smoking marijuana gives you. Well, that comes from THC.

Secondly, THC is addictive, which makes it a dangerous long-term solution. These two things combined also result in another downside. THC is illegal in many countries.

Now let’s get back to the benefits of THC which are a fact. THC binds to several receptors and thus provides its medical benefits. It has the highest affinity for binding to CB1 receptor and this makes it very effective. However, its high affinity for CB1 means that it rarely reaches other receptors, which means that the other two compounds with lower affinities for CB1 are effective against many more conditions.

As factual as its effectiveness is, its psychoactive features, addictiveness and focus on CB1 make it the least desirable option in this comparison.


It also comes from marijuana, but it is a lot different from THC. In scientific terms, CBD has far lower affinity for CB1 or CB2 which automatically makes it more effective than THC.

It is also not psychoactive and this feature also makes it far less addictive. In fact, some people claim that it is not addictive at all.

So, where is the problem?

First of all, you have probably noticed that the section on CBD has some uncertainties. This is so because it hasn’t been tested enough to draw certain conclusions. This lack of definite and proven standpoints makes CBD still illegal in many countries and this is normal. We do want all of our drugs thoroughly tested, so why would CBD be any different. There have been studies but they lack scope and number to be considered crystal-clear.

Secondly, CBD is an antagonist to some other CB1 and CB2 agonists which means that it can reduce their positive effects and some of them are actually naturally produced inside our bodies.

Which leads us to the most effective option.


PEA (Palmitoylethanolamide)

PEA is an endogenous compound that does not come from marijuana, or any similar source, so it is completely legal. It is also not psychoactive or addictive, regardless of the amounts you take in.

Speaking of large amounts, there is no way to overdose on PEA. If you take in more than you can absorb, it simply breaks down as it is a safe fatty acid amide.

OK, so PEA is safe and legal, but how effective is it?

More than CBD or THC. It binds to a larger number of receptors, which broadens its effectiveness; it does not interact with any other compound or drug which means it can be used with any other drug and it has absolutely no affinity for CB1 or CB2 receptors which also makes PEA more effective than THC and CBD.

OK, so PEA is safe, legal and efficient. But how researched is it?

Thoroughly. PEA has been known since the 1950s; extensive studies started in the 1970s and by late 1990s its mechanisms of operation were completely clear to scientists. This prompted more research and now we have about 400 studies all of which show that PEA is safe, completely natural and incredibly effective. In fact, several studies confirmed that it alleviates certain kinds of pain better than most famous and most commonly used painkillers. More and more doctors turn to PEA as their number one choice for reducing or even preventing pain and inflammation.

Another reason why PEA is a better option is that there is no habituation, which means that it can be used for chronic issues without any reduction in efficiency.

Essentially, PEA takes all of the benefits of THC and CBD and improves them while at the same time eliminating any downsides including the ones regarding efficacy, safety and even legal issues.