Lately we have encountered several patient experiences of people with severe hay fever that used the body’s own pain relief substance PEA (palmitoylethanolamide). Not only does this substance work as a pain reliever and anti-inflammatory, it also stabilizes the mast cells. Mast cells are inflammatory cells that play an important role in hay fever. In case of hay fever, these cells become overactive and as soon as the pollen are in the air, they start to produce substances that tickle the mucus membranes of the nose, airways and the eyes.

Here you can read the testimonies of 3 patients about the positive effects of PEA on hay fever. In the United States PEA is available as the supplement PeaCure.

These stories are very important, as many hay fever patients are dissatisfied with their antihistamine because of their side effects. Now there’s a good alternative!

 

Hay fever: disappears after using the natural substance palmitoylethanolamide! Back to life.

The first patient is a 50-year-old woman with life long asthmatic bronchitis and hay fever. As the wife of a professor in the medical faculty she always got the best treatments available, even pollen filters in the nose. However, the thorough work by the lung specialist couldn’t avoid that she locked herself in the house during springtime and was completely out of breath. After taking 1600mg PEA per day for 3 weeks (2 capsules twice a day) in early spring, just before pollen season started, it was remarkable that her asthma didn’t worsen when the spring started. Even better, she was able to spend the entire spring outside, and even sit against a tree, and when they were cutting grass. She had never been able to do that in her entire life. A maintenance dose of 400mg PEA capsule 3 times daily kept the hay fever away.

Hay fever and chronic shingles: disappeared!

The second patient wrote to us:

Good afternoon!

I’d like to let you know that I’m very happy with the use of PEA. I only started using it after 5 weeks of postherpetic pain (a shingles outbreak mid February)

Right after the shingles started I felt like a spotted cow, on top of the pain, over sensitivity and numbness. The pain in my body started between the collarbone and navel and went over to the side of my body and covered half of my back.  On top of that I was overwhelmed by severe lethargy: totally exhausted, out of nowhere!

This overall pain and strange sensations have decreased significantly after the first 10 days of taking the powder. My sleep improved, and because I need to take less paracetamol to get through the day the overwhelming lethargy also decreased slowly. Hurray, I will continue the treatment vigorously.

I have noticed another thing: my hay fever and eczema (a combination of psoriasis and atopic eczema) are GONE. Is there a connection here between the effects of PEA in relation to the mast cells and/or glia cells? The histamine used to be the cause of the appearance of eczema and allergic reactions.

 

Coughing, hay fever and enjoying life because of palmitoylethanolamide

The last patient was the wife of a medical specialist who had experienced hay fever and coughing all her life. Even though hay fever season had already started, she read about PEA for hay fever and started taking 1800mg per day. Her husband, a doctor, wrote us enthusiastically, which we are not used to when it comes to medical specialists. Her hay fever had disappeared and her cough episodes became very rare!

Meanwhile we have heard from several patients who have had similar experiences. People who had always had hay fever and started PEA treatment for neuropathic pain discovered their hay fever had gone when the pollen season started.

 

Hay fever, pollen and mast cells

Pollen is an allergen and hay fever the body’s response

Runny nose, red and teary eyes, shortness of breath and itching. Hay fever is one of the most common allergies. Hay fever means you are over sensitive to the pollen of certain plants, grasses and trees. These small pollen float along on the wind and spread over kilometers in from surrounding, which is why you can have symptoms even if you’re far away from a field or forest.

On a warm breezy day there can the millions of pollen in the air. When these pollen come in contact with your mucus membrane our immune cells produce certain substances which in turn activate another type of cell called mast cells. These mast cells contain a number of substances, including histamine, which is released from the cells. These substances create hay fever symptoms. Eczema, which is also common among hay fever patients and is also an allergic reaction, responds positively to PEA as well. [1] Eczema also responds well to PEA capsules and PEA cream. [2][3]

 

PEA: proven effective and safe

PEA is a proven inhibitor of the substances that are released by mast cells. [4] And this substance is produced in our own body. It’s the body’s own substance to calm mast cells. [5][6]

Many thousands of patients have been treated with PEA, usually for chronic pain and inflammation, or for allergic symptoms, with good results. There are no known side effects, seniors can take the supplement without problems and PeaCure had no negative influence on other medicine. On other pages of this website you can find more information on PEA.

This bodily fatty acid is available in the United States under the brand name PeaCure. This substance clearly shows to have an anti-allergic effect. [7][8][3][10]

According to the testimonials of these patients, PEA also proves to be a good alternative for hay fever during pollen season.

Because PEA has been extensively studied for many conditions and because it is effective and safe, but not clinically tested on many hay fever patients, we give PEA a green/orange light.

 

References

[1] Abramo F, Campora L, Albanese F, della Valle MF, Cristino L, Petrosino S, Di Marzo V, Miragliotta V1. | Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis. | BMC Vet Res. | 2014 Jan 14;10:21. doi: 10.1186/1746-6148-10-21.

[2] Kircik L. | A nonsteroidal lamellar matrix cream containing palmitoylethanolamide for the treatment of atopic dermatitis. | J Drugs Dermatol. | 2010 Apr;9(4):334-8.

[3] Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D’Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V. | Protective role of palmitoylethanolamide in contact allergic dermatitis. | Allergy. | 2010 Jun 1;65(6):698-711. doi: 10.1111/j.1398-9995.2009.02254.x. Epub 2009 Nov 11.

[4] Cerrato S1, Brazis P, Della Valle MF, Miolo A, Petrosino S, Di Marzo V, Puigdemont A. | Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. | Vet J. | 2012 Mar;191(3):377-82. doi: 10.1016/j.tvjl.2011.04.002. Epub 2011 May 20.

[5] De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S, Iuvone T. |Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. | Mol Pain. | 2011 Jan 10;7:3. doi: 10.1186/1744-8069-7-3.

[6] De Filippis D, D’Amico A, Iuvone T. | Cannabinomimetic control of mast cell mediator release: new perspective in chronic inflammation. | J Neuroendocrinol. | 2008 May;20 Suppl 1:20-5. doi: 10.1111/j.1365-2826.2008.01674.x.

[7] Kircik L. | A nonsteroidal lamellar matrix cream containing palmitoylethanolamide for the treatment of atopic dermatitis. | J Drugs Dermatol. | 2010 Apr;9(4):334-8.

[8] De Petrocellis L, Melck D, Bisogno T, Di Marzo V. | Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders. | Chem Phys Lipids. | 2000 Nov;108(1-2):191-209.

[9] Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D’Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V. | Protective role of palmitoylethanolamide in contact allergic dermatitis. | Allergy. | 2010 Jun 1;65(6):698-711. doi: 10.1111/j.1398-9995.2009.02254.x. Epub 2009 Nov 11.

[10] Eberlein B, Eicke C, Reinhardt HW, Ring J. | Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). | J Eur Acad Dermatol Venereol. | 2008 Jan;22(1):73-82. doi: 10.1111/j.1468-3083.2007.02351.x.