2015: The flu vaccine is ineffective! The viruses have mutated, now what do we do? Fortunately there’s an effective supplement, palmitoylethanolamide (PeaCure)! In industrialized countries worldwide, 5 million people get sick and over 500.000 people lose their life due to flu. The natural substance palmitoylethanolamide decreases the chance of catching flu or colds. And what if you already have the flu or a cold? Then taking the supplement will quickly decrease the symptoms.

The effects of this natural bodily compound (palmitoylethanolamide) have been proven by a number of extensive (double blind, placebo controlled) clinical studies.

In this time, when the flu vaccine is being criticized from all sides and the value of drugs like Tamiflu are altogether unclear, having an alternative for flu and common cold is of great importance.

We’re talking about the all-natural substance called palmitoylethanolamide, which is produced by the body. We will continue to call the substance PEA.

In the U.S. PEA is available as a supplement named PeaCure. PEA is a substance that is created in the cells of our body to protect us from infections. In case of flu and common cold, this system can get a little support!

PeaCure contains pure palmitoylethanolamide, without any added pharmaceutical or chemical fillers.

We will start with an example and after that will discuss the science around vaccines, Tamiflu as well as the results form studies that were conducted around PEA as related to flu and colds.


A patient with oncoming flu

A man of around 50 years of age, who is a manager and overworked, often gets flu or colds. He can feel it coming due to a runny nose and often ends up being under the wool for days. Two times a day 800mg PeaCure under the tongue and, contrary to usual, the symptoms disappeared and he could continue working.  The symptoms decreased on the second day and were gone entirely on the third day.

This is an example of the anti-flu properties of PeaCure. Below we will discuss 5 clinical studies conducted on over 2000 patients, which prove the safety and effectiveness of this natural anti-flu supplement. But first a chapter about the pharmaceutical substances and the vaccines.


Vaccines and pharmaceutical means against flu: questioning

Now that we know that pharmaceutical anti-flu medicine like Oseltamivir (Tamiflu) can have nasty side-effects, an may not even work may not even work, it seems that the natural and body produced substance, the supplement PEA, offers a natural effective alternative without side-effects. This theme has received a lot of attention recently! We recently published about this in an international journal on infections, together with professor Witkamp from Wageningen.

The flu vaccine has been a controversial subject as well. Even amongst the most regarded experts we see that opinions differentiate. Recent extensive studies about the effectiveness of flu vaccines haven’t been very optimistic. [1] [2][3] [4]

Apart from the question is fly vaccine is desirable, it is important to know that the natural bodily compound PEA is effective in preventing flu, as was proven by 5 different randomized and double blind studies conducted on more than 3000 adults.

In another study conducted on 457 school children the substance also proved to be useful and effective for children.

The preventative and treatment dose for flu and colds is 1200-1400mg per day for the first 2 weeks followed by 400mg twice a day after that. This ensures good support to the immune system during the flu period.

PEA has been used by many hundreds of thousands of people nowadays without any report of negative side effects. The substance can also be effectively used with senior patients. No negative interactions with other medicine or food are know.

PEA is produced by our own body as a response to infections, inflammation and pain. By supplementing this substance during fly and common cold you help your body to restore balance faster.

PEA’s supportive role towards our immune system during flu and colds has been known since last century and recently went through a revival as many studies have been done around this substance that showed that PEA has anti-inflammatory, immune supporting (and pain relieving) properties.


Palmitoylethanolamide for flu

The table below shows a summary of 5 extensive clinical studies that were done on over 3000 people combined, of which 1527 were given PEA.

Study PEA (n=) Placebo (n=) Percentage of protection Significance
Masek 1 223 221 45 % P < 0,05
Masek 2 222 216 32 % P < 0.05
Kahlich 1 436 456 34% P < 0,0002
Kahlich 2 411 199 52% P < 0,0002
Kahlich 3 235 118 59% P < 0,0002


The table shows that the chances of catching flu or colds on PEA treatment decreased with between 32% and 59%. That is a considerable amount. For vaccines it was said this used to be between 60% and 80%.

PEA was also tested on children, even as young as 4 years old.

In 1997 a double blinded study on 457 school children also indicated that the use of PEA significantly decreased the inflammation of the respiratory system.

None of the studies reported any side effects. Plesnik, one of the main researchers noted:

“No side effects were registered after several years of clinical testing of PEA in military and civilian communities”

Schmidt, another researcher, summarized the results of al the studies in 1990 as follows:

“ The specific property (of PEA) as an inducer of non-specific resistance led to several clinical trials to evaluate the prophylactic efficacy of N-acylethanolamine in upper respiratory tract viral infections.

In several clinical double-blind trials, repeated daily intake of N-palmitoylethanolamine (Impulsin, 30 mg/kg) reduced the incidence and severity of respiratory tract infections and also markedly diminished the number of episodes of fever, headache, and sore throat.”

The prevention of flu and colds has been portrayed in both sections of the research. In all three studies it clearly showed that Impulsin (PEA) significantly decrease the chance of flu and colds. The use of PEA reduced the chance of colds and flu with between 34-59%, an impressive number.

There were several other large studies in this time period that showed some additional results that displayed that PEA had a clear effect and significantly reduced the chance of colds and flu.

As an example we will discuss in more detail the results of several large studies, as described by Masek and colleagues of the  ‘Institute of Pharmacology, Czechoslovak Academy of Sciences’, and the ‘Military Institute of Hygiene, Epidemiology and Microbiology’, both in Prague (Czech Republic). The studies were conducted on people living closely together (military) and where flu easily spread amongst each other. The studies used PEA, which at that time was commercially called Impulsin.

Despite the fact that the study was conducted several decennia ago, the research is still reliable and was conducted double blinded and randomized. We quote:

Volunteers were allocated to PEA or placebo treament in a strictly double-blind random manner and the code was not broken until the data had been prepared for statistical analysis.

Each subject was given a coded bottle containing 72 tablets. Half the bottles contained Impulsin, 300 mg/tablets, and the others contained only placebo tablets. The tablets were indistinguishable in appearance and taste.

Each volunteer received a description of the purpose and method of the study. Subjects were instructed to swallow two tablets, three times a day, for twelve consecutive days. The periods of six or eight weeks were evaluated in several ways; the first and last weeks were omitted to produce 6-week intervals for assessment.

468 volunteers, who all worked for the Skoda car factory, were included in the first study. The second study consisted of 918 volunteers, between the age of 18-20 and belonged in the military.

The first study showed that taking palmitoylethanolamide decreased the spells of fever, and other symptoms like fever and headache, greatly with 45,5%. The total amount of days that the flu lasted also decreased with taking Impulsin, as is shown in the table above.

In the military group the substance also showed a measurable and favorable effect on the appearance of flu and colds.

The corresponding numbers for the 8 week period were 301/436 (69%) volunteers on Impulsin remained healthy, as did 266/465 (57%) on the placebo. Thus, the incidence of disease amongst subjects who received Impulsin was 40% lower in the 6 week study and 32% lower in the 8 week period; the reductions were highly significant (p<0.0005).  

These studies both showed that PEA can be safely prescribed and that there are measurable effects that indicate a protective properties of PEA during flu and colds.


Conclusion: palmitoylethanolamide useful and safe for flu and colds.

The conclusion of the authors was as follows:

The results of both large-scale double-blind trials suggest that prophylactic administration of Impulsin would be useful in the prevention of virus infections of the respiratory tract of man. This is of considerable importance, since disability due to acute respiratory illness causes great economic loss every year in many countries.

It was recently discovered that our own immune system helps us to normalize unmanageable infections, like the flu. [7] Which makes it easy to understand PEA, a bodily substance that is created to as a response to inflammation.


Palmitoylethanolamide: anti-inflammatory

At that time in the 70’s, it was thought that PEA had an unspecific  anti-inflammatory effect. Experiments with animals during that time already showed that PEA could increase immunity against viral infection and respiratory infections. [8][9]

Positive results were also described about infection amongst children and diligent research was being conducted to discover the working mechanisms, which at that time couldn’t yet be found. [10][11][5][13] At that time people suspected it influenced the white blood cells (T and B cells). Only 10-20 years later they found this to be incorrect, when it was found that the substance supports the immune system by decreasing inflammation. [14] [15] [16] [17] [18]


PEA: How to use it during fly and cold?

For impending fly, we think it is best to take 2 capsules twice a day, which is a total of 1600-2400 mg PeaCure a day. After 2 weeks the dose can be adapted to 1 capsule 3 times a day. For severe fly symptoms PeaCure may work faster in a high dose of 2400mg per day.


Evaluation of PEA for flu and colds

Palmitoylethanolamide is found in all sorts of living animals and is a substance produced by the body. PEA is also found in certain foods like eggs and peanuts.

Between 1972 and now many thousands of patients have been treated with PEA and no notable side effects have been reported. This totally different for pharmaceutical anti-fly drugs like Tamiflu, which have quite a few negative side effects. [19]

There have been no negative interactions of PEA with other medicine, including the pharmaceutical anti-fly drugs.

In 6 different double blind studies PEA clearly proves to be effective against fly (much like an oral flu vaccine), and common cold. This also differs from the regular pharmaceutical anti-flu medicine, of which it is highly unclear if they are effective at all.  [20][19] [22]

Furthermore, dozens of other clinical studies have been published concerning PEA, each of which showing the safety and effectiveness of this substance.

Hence a green light for PEA to treat and prevent flu and colds. PEA is an alternative to treat and prevent flu and colds. Considering the balance between effectiveness and side-effects, PEA is definitely a good choice.

PEA capsules are available in 400mg. The recommended dose to prevent flu and colds is 400mg 2-3 times a day. For acute symptoms double the dose and take it immediately when the first symptoms appear!




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[21] Smieja M. | ACP Journal Club. Review: oseltamivir relieves symptoms but does not reduce hospitalizations in influenza. | Ann Intern Med. | 2012 Sep 18;157(6):JC3-5. doi: 10.7326/0003-4819-157-6-201209180-02005.

[22] Hsu J, Santesso N, Mustafa R, Brozek J, Chen YL, Hopkins JP, Cheung A, Hovhannisyan G, Ivanova L, Flottorp SA, Saeterdal I, Wong AD, Tian J, Uyeki TM, Akl EA, Alonso-Coello P, Smaill F, Schünemann HJ. | Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies. | Ann Intern Med. | 2012 Apr 3;156(7):512-24. doi: 10.7326/0003-4819-156-7-201204030-00411. Epub 2012 Feb 27.